Benzenamine, N,4-dimethyl- → (4-Methyl-phenyl)-methyl-quinazolin-4-yl-amine

HRID 1876084

Reaktionsgleichung

Reaktionsgleichung von HRID 1876084
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:12][C:13]1[CH:20]=[CH:19][C:16]([NH:17][CH3:18])=[CH:15][CH:14]=1>>[CH3:12][C:13]1[CH:20]=[CH:19][C:16]([N:17]([CH3:18])[C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 12165Benzenamine, N,4-dimethyl-HCID 788644-Chloroquinazoline

Produkt 1

HCID 11276744(4-Methyl-phenyl)-methyl-quinazolin-4-yl-amine

Versuchsvorschrift

The title compound was prepared from 4-chloroquinazoline and 4-methyl-N-methylaniline by a procedure similar to Example 28 (80% yield). 1H NMR (CDCl3): 8.23 (s, 1H), 7.82 (d, J=8.4 Hz, 1H), 7.57 (ddd, J=8.4, 6.3 and 1.8 Hz, 1H), 7.17-7.20 (m, 2H), 7.00-7.10 (m, 4H), 3.61 (s, 3H), 2.39 (s, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-782953df1f584f7f9a56bbf1e4afffa3
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08309562B2

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