Imidazole → HCID 59543005, Verbindung

The compound (3.7 g, 10.2 mmol) prepared in Example 32 was dissolved in tetrahydrofuran (100 ml). Imidazole (2.1 g, 30.6 mmol), triphenylphosphine (4.0 g, 15.3 mmol), and iodine (3.9 g, 15.3 mmol) were added thereto, and the mixture was stirred for 8 h at 0° C.˜room temperature. After completion of the reaction, ethyl acetate (100 ml) was added, and the mixture was washed with water (2×100 ml). The organic layer was concentrated, and the residue was separated by column chromatography to give the title compound (2.0 g, 4.07 mmol, Yield 40%).

1. additionwas added
2. washthe mixture was washed with water (2×100 ml)
3. concentrationThe organic layer was concentrated
4. customthe residue was separated by column chromatography

ORD-Eintrag

ord-56358d159bec4bcaac345a8c8b772dd7

Quelldatensatz

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08309586B2