Diethyl (cyanomethyl)phosphonate → Tert-butyl 4-(3-cyanoprop-2-en-1-yl)piperidine-1-carboxylate

HRID 1876841Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1876841
CC(C)([O-])C.[K+].[C:7]([CH2:9]P(=O)(OCC)OCC)#[N:8].O=[CH:19][CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]1>O1CCCC1>[C:7]([CH:9]=[CH:19][CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]1)#[N:8]

Komponenten

5

Edukt 3

HCID 75676Diethyl (cyanomethyl)phosphonateHCID 10353694tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylateHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 67155885Tert-butyl 4-(3-cyanoprop-2-en-1-yl)piperidine-1-carboxylateAusbeute 75,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

To a solution of 1.0 M of potassium tert-butoxide in tetrahydrofuran (45.8 mL) at 0° C. was added dropwise a solution of diethyl cyanomethylphosphonate (7.77 mL, 0.0480 mol) in tetrahydrofuran (58.39 mL). The reaction was warmed to room temperature and then cooled at 0° C. again. To the reaction mixture was added a solution of tert-butyl 4-(2-oxoethyl)piperidine-1-carboxylate (9.91 g, 0.0436 mol) in tetrahydrofuran (11.7 mL). The reaction was allowed to warm up to room temperature and stirred at room temperature overnight. After being quenched with water, the mixture was extracted with EtOAc. The combined organic layers were washed with brine, dried and evaporated to dryness. The crude mixture was purified on silica gel, eluting with 0 to 40% EtOAc in hexanes, to give the desired product (8.22 g, 75% in 2 steps). LCMS (M+Na) 273.0.

Aufarbeitung

  1. temperaturecooled at 0° C. again
  2. temperatureto warm up to room temperature
  3. customAfter being quenched with water
  4. extractionthe mixture was extracted with EtOAc
  5. washThe combined organic layers were washed with brine
  6. customdried
  7. customevaporated to dryness
  8. customThe crude mixture was purified on silica gel
  9. washeluting with 0 to 40% EtOAc in hexanes

Quellen und Nachweise

ORD-Eintrag
ord-61f9ed2b28bd4621b70b36aae1e70578
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08309718B2

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