Methyl 4-methyl-3-oxopentanoate → Methyl 2-isopropyl-5-[4-(trifluoromethyl)phenyl]-3-furoate
Reaktionsgleichung
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].[CH3:15][CH:16]([CH3:24])[C:17](=O)[CH2:18][C:19]([O:21][CH3:22])=[O:20]>>[CH:16]([C:17]1[O:4][C:3]([C:5]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=2)=[CH:2][C:18]=1[C:19]([O:21][CH3:22])=[O:20])([CH3:24])[CH3:15]Komponenten
3
Versuchsvorschrift
An operation similar to that in Example 1 (1) was performed using 2-chloro-4′-(trifluoromethyl)acetophenone (13.4 g) and methyl 4-methyl-3-oxopentanoate (7.2 g) to give the title compound (5.7 g, 36%) as an oil.
Quellen und Nachweise
- ORD-Eintrag
- ord-391e3ec9bb9e4646a84e5e958134df10
- Quelldatensatz
- uspto-grants-2012_11