(4-Fluoro-2-methylphenyl)boronic acid → Methyl 5-(4-fluoro-2-methylphenyl)-2-methyl-3-furoate

HRID 1876977

Reaktionsgleichung

Reaktionsgleichung von HRID 1876977
Br[C:2]1[O:6][C:5]([CH3:7])=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[C:15]([CH3:22])[CH:14]=1>>[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[O:6][C:5]([CH3:7])=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=2)=[C:15]([CH3:22])[CH:14]=1

Komponenten

3

Edukt 2

HCID 2734665(4-Fluoro-2-methylphenyl)boronic acidHCID 15534190Methyl 5-bromo-2-methylfuran-3-carboxylate

Produkt 1

HCID 68515415Methyl 5-(4-fluoro-2-methylphenyl)-2-methyl-3-furoateAusbeute 85 %

Versuchsvorschrift

An operation similar to that in Example 49 (2) was performed using methyl 5-bromo-2-methyl-3-furoate (4.4 g) and 4-fluoro-2-methylphenylboronic acid (3.7 g) to give the title compound (4.2 g, 85%) as a white crystal.

Quellen und Nachweise

ORD-Eintrag
ord-e0684a6fff9347809873f7e39b59413b
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08309580B2

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