Thionyl Chloride → 4-[chloro(2-methyl-5-phenylfuran-3-yl)methyl]tetrahydro-2H-pyran

HRID 1877037

Reaktionsgleichung

Reaktionsgleichung von HRID 1877037
[CH3:1][C:2]1[O:3][C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][C:6]=1[CH:7]([CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)O.S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[Cl:23][CH:7]([C:6]1[CH:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:3][C:2]=1[CH3:1])[CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 68514112(2-methyl-5-phenylfuran-3-yl)(tetrahydro-2H-pyran-4-yl)methanol

Produkt 1

HCID 685124234-[chloro(2-methyl-5-phenylfuran-3-yl)methyl]tetrahydro-2H-pyranAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of (2-methyl-5-phenylfuran-3-yl) (tetrahydro-2H-pyran-4-yl)methanol (1.8 g) in toluene (20 mL) was added thionyl chloride (1.4 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to give the title compound (1.9 g, 100%) as an oil.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0e72f28db2894c088dc58f41dc2592a1
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08309580B2

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