Reaktionsgleichung
F[C:2]1[CH:9]=[C:8]([N:10]2[C:22]3[CH:21]=[CH:20][CH:19]=[C:18]([C:23]4[NH:27][C:26]5[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:25]=5[N:24]=4)[C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH:39]1([NH2:45])[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1.[OH-:46].[Na+].OO>CS(C)=O.C(O)C>[CH:39]1([NH:45][C:2]2[CH:9]=[C:8]([N:10]3[C:22]4[CH:21]=[CH:20][CH:19]=[C:18]([C:23]5[NH:27][C:26]6[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:25]=6[N:24]=5)[C:17]=4[C:16]4[C:11]3=[CH:12][CH:13]=[CH:14][CH:15]=4)[CH:7]=[CH:6][C:3]=2[C:4]([NH2:5])=[O:46])[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1Komponenten
8
Edukt 5
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
The process is carried out as in stage 3 of Example 3, but using 100 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 263 mg of potassium carbonate and 94 mg of cyclohexylamine in 0.8 ml of dimethyl sulphoxide. 0.4 ml of a 1M aqueous solution of sodium hydroxide, 0.4 ml of a 30% aqueous solution of hydrogen peroxide and 2 ml of ethanol are then added to the reaction medium. After treatment and purification as in stage 3 of Example 3, 40 mg of 2-cyclohexylamino-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide are thus obtained in the form of a white solid, the characteristics of which are the following:
Aufarbeitung
- customobtained
- customAfter treatment and purification as in stage 3 of Example 3, 40 mg of 2-cyclohexylamino-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide
- customare thus obtained in the form of a white solid
Quellen und Nachweise
- ORD-Eintrag
- ord-26725bbae2b44aba84b559bff6d73e75
- Quelldatensatz
- uspto-grants-2012_11
- Patentnummer
- US08309721B2
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