Methanol → HCID 178470201, Verbindung
Reaktionsgleichung
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:7]=[N:8][C:9]([C:12](=[N:14]O)[NH2:13])=[CH:10][CH:11]=1)=[O:4].[CH2:16]([O:18][C:19]([C:21]#[C:22][C:23]([O:25]CC)=O)=[O:20])[CH3:17].C[OH:29]>>[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:14]=[C:21]([C:19]([O:18][CH2:16][CH3:17])=[O:20])[C:22]([OH:29])=[C:23]([OH:25])[N:13]=2)=[N:8][CH:7]=1)=[O:4]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 142.5 °C
Versuchsvorschrift
A mixture of compound of example 4 (2.0 g, 8.75 mmol) and diethylacetylene dicarboxylate (0.34 g, 2.36 mmol) was stirred in methanol (20 mL) at a temperature in the range of 60-65° C. for 4 hours. Methanol was removed under reduced pressure and xylene (20 mL) was added and the reaction mixture was heated at a temperature in the range of 140-145° C. for 18 hours. A brownish colored solid obtained was removed by filtration, and the reaction mixture was again stirred at the same temperature for 8 hours to obtain the title compound.