Cyclopropanemethanamine → HCID 57917614, Verbindung

HRID 1878439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878439
[NH2:1][C:2]1[CH:32]=[CH:31][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:16]=[C:17]([CH:28]=[CH:29][CH:30]=3)[C:18]([NH:20][C:21]([C:26]#[N:27])([CH:23]3[CH2:25][CH2:24]3)[CH3:22])=[O:19])[CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[F:33].C1C([N+]([O-])=O)=CC=C([Cl-][C:44]([O-])=[O:45])C=1.[CH:47]1([CH2:50][NH2:51])[CH2:49][CH2:48]1>ClCCl>[C:26]([C:21]([NH:20][C:18](=[O:19])[C:17]1[CH:28]=[CH:29][CH:30]=[C:15]([CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:6](=[O:7])[C:5]3[CH:31]=[CH:32][C:2]([NH:1][C:44]([NH:51][CH2:50][CH:47]4[CH2:49][CH2:48]4)=[O:45])=[C:3]([F:33])[CH:4]=3)[CH2:13][CH2:12]2)[CH:16]=1)([CH:23]1[CH2:25][CH2:24]1)[CH3:22])#[N:27]

Komponenten

4

Edukt 2

HCID 75646CyclopropanemethanamineHCID 579176753-((4-(4-Amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-(1-cyano-1-cyclopropylethyl)benzamide

Produkt 1

HCID 57917614HCID 57917614, VerbindungAusbeute 42 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-((4-(4-Amino-3-fluorobenzoyl)piperazin-1-yl)methyl)—N-(1-cyano-1-cyclopropyl-ethyl)benzamide (49 mg, 0.109 mmol) was stirred In dichloromethane at room temperature. 4-Nitrophenylchloroformate (22 mg, 0.109 mmol) was added and the reaction mixture stirred for 30 minutes. Cyclopropylmethylamine (23 mg, 0.327 mmol) was added and the reaction allowed to stir for 30 minutes at room temperature. The reaction was concentrated under reduced pressure and the resulting residue purified by silica column chromatography to afford the title compound (25 mg). MS (ESI) m/z 547.5 [M+H]+

Aufarbeitung

  1. stirringto stir for 30 minutes at room temperature
  2. concentrationThe reaction was concentrated under reduced pressure
  3. customthe resulting residue purified by silica column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-1603cbe733c74f4fbe0ec3929d9fa2fa
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314091B2

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