3-Acetylbenzaldehyde → HCID 70999655, Verbindung

HRID 1878587Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878587
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)(=[O:26])[CH3:25]>C(O)C>[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)(=[O:26])[CH3:25]

Komponenten

4

Edukt 2

HCID 6434363-AcetylbenzaldehydeHCID 70867116HCID 70867116, Verbindung

Produkt 1

HCID 70999655HCID 70999655, VerbindungAusbeute 77,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.6 mg, 0.0983 mM), then 3-acetyl-benzaldehyde (14.6 mg, 0.0983 mM) was added to the solution and the mixture was stirred at room temperature overnight. The reaction liquid was filtered and then the resulting solid was washed with diethyl ether to thus give the title compound (33.6 mg, yield: 77%).

Aufarbeitung

  1. customThe reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-dfb777223e874aff920bdea5ebf58b86
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314098B2

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