3-Isopropylbenzaldehyde → HCID 77933899, Verbindung

HRID 1878589Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878589
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)([CH3:26])[CH3:25]>C(O)C>[CH:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)([CH3:26])[CH3:25]

Komponenten

4

Edukt 2

HCID 5206803-IsopropylbenzaldehydeHCID 70867116HCID 70867116, Verbindung

Produkt 1

HCID 77933899HCID 77933899, VerbindungAusbeute 26,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.1 mg, 0.0967 mM), then 3-isopropyl-benzaldehyde (14.3 mg, 0.0967 mM) was added to the solution and the mixture was stirred at room temperature overnight. The solvent was distilled off from this reaction liquid, the resulting residue was purified by the reversed phase HPLC and then subjected to a desalting treatment to thus give the title compound (11.3 mg, yield: 26%).

Aufarbeitung

  1. distillationThe solvent was distilled off from this reaction liquid
  2. customthe resulting residue was purified by the reversed phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-055a341b2fd14d15b0f9319f12ba2c77
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314098B2

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