4-(5-Bromo-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine → 4-(5-Bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine

HRID 1878594Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878594
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]3[CH:23]=[CH:22][NH:21][C:10]=3[N:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16](C)[N:15]=3)[N:13]=2)[CH:5]=[N:6][CH:7]=1.IC1C2C=CNC=2N=C(C2C=CC=C(C)N=2)N=1.IC1C2C=CNC=2N=C(C2C=CC=CN=2)N=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]3[CH:23]=[CH:22][NH:21][C:10]=3[N:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[N:13]=2)[CH:5]=[N:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 441944484-(5-Bromo-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidineHCID 866324294-iodo-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidineHCID 866324304-iodo-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine2×

Produkt 1

HCID 687601424-(5-Bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine

Versuchsvorschrift

4-(5-Bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine is prepared by an analogous method to that for 4-(5-bromo-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (Example 16) by replacing 4-iodo-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (Intermediate 3) with 4-iodo-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine (Intermediate 4).

Quellen und Nachweise

ORD-Eintrag
ord-5144dae81c5e4dacb80d0efba6205430
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314112B2

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