Sodium Hydroxide → 6-Bromo-4-chloro-1H-pyrrolo[2,3-B]pyridine

HRID 1878612Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1878612
[Br:1][C:2]1[N:7]=[C:6]2[N:8](C(C3C=CC=CC=3)=O)[CH:9]=[CH:10][C:5]2=[C:4]([Cl:19])[CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[C:4]([Cl:19])[CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 73014178(6-Bromo-4-chloro-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone

Produkt 1

HCID 247295876-Bromo-4-chloro-1H-pyrrolo[2,3-B]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

(6-Bromo-4-chloro-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone (1 eq, 69.7 mmol, 23.4 g) is dissolved in MeOH (300 ml), then aqueous NaOH solution (1 M, 120 ml) is added and the resulting mixture is stirred for 18 h at r.t. The mixture is extracted with DCM and EtOAc, the extracts are combined and the solvents are removed in vacuo. Recrystallization from MeOH yields the title compound; [M+H]+=231.

Aufarbeitung

  1. extractionThe mixture is extracted with DCM and EtOAc
  2. customthe solvents are removed in vacuo
  3. customRecrystallization from MeOH

Quellen und Nachweise

ORD-Eintrag
ord-34d7a9f803954f57bee3507ac7c79743
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08314112B2

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