1-(4-fluorophenyl)-N-methylmethanamine → 2-(6-{[2-(4-Methoxy-phenoxy)-ethyl]-methyl-amino}-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro-benzylamide

Beteiligte Stoffe

Reaktionsschritte

Following the procedure described in Example 14, making variations as required to replace 4-fluoro-N-methyl-benzylamine with [2-(4-methoxy-phenoxy)-ethyl]-methyl-amine to react with 2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid 4-fluoro-benzylamide, the title compound was obtained in 80% yield. 1H NMR (400 MHz, CD2Cl2) δ 8.50 (s, 1H), 8.04 (s, 1H), 7.31-7.38 (m, 2H), 7.02-7.09 (m, 2H), 6.72-6.82 (m, 4H), 6.25 (bs, 1H), 4.55-4.59 (m, 2H), 4.18-4.23 (m, 2H), 4.01-4.08 (m, 2H), 3.69 (s, 3H), 3.31 (s, 3H), 2.71 (s, 3H); MS (ES+) m/z 508.2 (M+1), Rt=1.57 min.

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