Cesium carbonate → 2-Bromo-6-(8-tert-butyl-5-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]diazepin-4-yl)-benzaldehyde

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

8-tert-Butyl-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one (420 mg, 2 mmol), 2,6-Dibromo-benzaldehyde (2.03 g, 8 mmol, 3eq), Xanthphos (22 mg, 0.02eq), and cesium carbonate (1.23 g, 4 mmol, 2 eq) were taken up in dioxane (5.0 mL) and a stream of argon gas was bubbled through the mixture for 1 minute. The catalyst Pd(dba)2 (33 mg, 0.03 eq) was added and argon was bubbled through for an additional minute. The resulting mixture was sealed under argon and stirred at 100° C. for 18 hours. The reaction was cooled and filtered. The collected solid was triturated with water and filtered to give a solid. The dioxane filtrate was combined with this solid, the solvent removed under vacuum, and the residue chromatographed, eluting with 50% ethyl acetate in hexanes gave a solid, 81 mg. (M+H)+=402.

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