HCID 59327113, Verbindung → Tert-butyl 4-(2-(4-(ethoxycarbonyl)phenoxy)pyridin-3-YL)piperidine-1-carboxylate

HRID 1880141

Reaktionsgleichung

Reaktionsgleichung von HRID 1880141
[CH2:1]([O:3][C:4]([C:6]1[CH:31]=[CH:30][C:9]([O:10][C:11]2[C:16]([C:17]3[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]=3)=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2]>CCO.[OH-].[OH-].[Pd+2]>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([O:10][C:11]2[C:16]([CH:17]3[CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:24])[CH2:21][CH2:22]3)=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:30][CH:31]=1)=[O:5])[CH3:2]

Komponenten

4

Edukt 1

HCID 59327113HCID 59327113, Verbindung

Produkt 1

HCID 59326865Tert-butyl 4-(2-(4-(ethoxycarbonyl)phenoxy)pyridin-3-YL)piperidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl 4-(2-(4-(ethoxycarbonyl)phenoxy)pyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (5.89 g, 13.87 mmol) and palladium hydroxide on carbon (0.950 g, 1.353 mmol) in EtOH (50 mL) was evacuated/purged with hydrogen (1 atm, 3×). After stirring at rt overnight. The mixture was filtered through a pad of Celite and the filtrate was concentrated to dryness to give a light-yellow oil. MS m/z: 427.1 [M+1].

Aufarbeitung

  1. customwas evacuated/purged with hydrogen (1 atm, 3×)
  2. filtrationThe mixture was filtered through a pad of Celite
  3. concentrationthe filtrate was concentrated to dryness
  4. customto give a light-yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-f247155a94ad4058a61b4bf159cec40a
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318718B2

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