HCID 59327230, Verbindung → 2-Fluoro-3-(tetrahydrofuran-3-YL)pyridine
Reaktionsgleichung
[O:1]1[CH:5]=[CH:4][CH:3]([C:6]2[C:7]([F:12])=[N:8][CH:9]=[CH:10][CH:11]=2)[CH2:2]1>C1COCC1.[OH-].[Pd+2].[OH-]>[F:12][C:7]1[C:6]([CH:3]2[CH2:4][CH2:5][O:1][CH2:2]2)=[CH:11][CH:10]=[CH:9][N:8]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of 3-(2,3-dihydrofuran-3-yl)-2-fluoropyridine (5.26 g, 31.8 mmol) and palladium hydroxide, 20 wt % pd (dry basis) on carbon, wet (2.500 g, 3.56 mmol) in THF (50 mL) was evacuated/purged with hydrogen (3×). The mixture was stirred vigorously under hydrogen (1 atm) at rt overnight. The mixture was filtered through a pad of Celite and the filtrate was concentrated to dryness to give a clear colorless oil. MS (ESI, pos. ion) m/z: 168.1 (M+1).
Aufarbeitung
- customwas evacuated/purged with hydrogen (3×)
- filtrationThe mixture was filtered through a pad of Celite
- concentrationthe filtrate was concentrated to dryness
- customto give a clear colorless oil
Quellen und Nachweise
- ORD-Eintrag
- ord-cda29c19338f4f898cdb2f4d44cf21ab
- Quelldatensatz
- uspto-grants-2012_11
- Patentnummer
- US08318718B2
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