Trifluoroacetic acid → Trifluoroacetic acid
Reaktionsgleichung
[CH3:1][C:2]1[S:6][C:5]([NH:7]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[S:6][C:5]([NH2:7])=[CH:4][CH:3]=1.[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16]Komponenten
5
Edukt 2
Produkt 2
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of tert-butyl 5-methylthiophen-2-ylcarbamate (0.825 g, 3.87 mmol) in CH2Cl2 (10 mL) and TFA (6 mL) wad stirred at room temperature for 20 h. Solvents was removed in vacuo to give 5-methylthiophen-2-amine as trifluoroacetic acid salt (0.870 g).
Aufarbeitung
- customSolvents was removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-195dcb3138fa4bd89055adc1f0a62244
- Quelldatensatz
- uspto-grants-2012_11
- Patentnummer
- US08318755B2
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