Ethanol → Ethyl 3-(cyclopentylamino)-2-hydroxy-2-methylpropanoate
Reaktionsgleichung
[CH3:1][C:2]1([C:5]([O:7][CH3:8])=[O:6])[O:4][CH2:3]1.[CH:9]1([NH2:14])[CH2:13][CH2:12][CH2:11][CH2:10]1.[CH2:15](O)C>>[CH:9]1([NH:14][CH2:3][C:2]([OH:4])([CH3:1])[C:5]([O:7][CH2:8][CH3:15])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10]1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
A mixture of methyl 2-methylglycidate (3.18 g, 27 mmol) and cyclopentylamine (4 mL, 41 mmol) in ethanol (50 mL) was heated at 80° C. for 3 d. The reaction mixture was then concentrated, diluted to EtOAc, washed by NaHCO3, brine and water. Organic layer was dried, concentrated to give a residue which is used for next step without further purification (3.9 g, 60%). [M+H] calc'd for C11H21NO3, 216; found 216.