Boron tribromide → 478400-03-2

HRID 1881160Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1881160
C[O:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[C:11]([O:16]C)[C:12]([O:14]C)=[CH:13][C:7]=2[C:6]=1[Cl:18])=[O:4].B(Br)(Br)Br>ClCCl>[Cl:18][C:6]1[C:7]2[CH:13]=[C:12]([OH:14])[C:11]([OH:16])=[CH:10][C:8]=2[S:9][C:5]=1[C:3]([OH:4])=[O:2]

Komponenten

4

Edukt 2

HCID 25134Boron tribromideHCID 12521856HCID 12521856, Verbindung

Produkt 1

HCID 13575863478400-03-2

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-20 °C

Versuchsvorschrift

3-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carboxylic acid methyl ester (0.2 g) was suspended in dichloromethane (10 ml) under nitrogen, cooled to −20° C. and boron tribromide (0.4 ml) was added. The resultant mixture was stirred at −20° C. for 30 min and then in cool overnight. The mixture was poured into ice-cold water, extracted into ethyl acetate and evaporated to dryness. The product was used for the next step without any purification.

Aufarbeitung

  1. additionThe mixture was poured into ice-cold water
  2. extractionextracted into ethyl acetate
  3. customevaporated to dryness
  4. customThe product was used for the next step without any purification

Quellen und Nachweise

ORD-Eintrag
ord-504c820e90a945e1838d01b6b3ba3180
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318785B2

Notizen zur Reaktion

Wird geladen…