Nitric Acid → 2-Methyl-7-nitro-1,3-benzothiazole-5,6-diol

HRID 1881176Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1881176
[CH3:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([OH:11])[C:8]([OH:12])=[CH:7][C:5]=2[N:6]=1.[N+:13]([O-])([OH:15])=[O:14]>C(OCC)(=O)C.ClCCl>[CH3:1][C:2]1[S:3][C:4]2[C:10]([N+:13]([O-:15])=[O:14])=[C:9]([OH:11])[C:8]([OH:12])=[CH:7][C:5]=2[N:6]=1

Komponenten

5

Edukt 2

HCID 944Nitric AcidHCID 7369402-methyl-1,3-benzothiazole-5,6-diol

Produkt 1

HCID 159831022-Methyl-7-nitro-1,3-benzothiazole-5,6-diol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Methyl-benzothiazole-5,6-diol was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.38 ml) was gradually added at 20° C. into. The solution was stirred 10 min at room temperature and then it was poured into ice water and extracted into ethyl acetate and evaporated. The product was purified by column chromatography using toluene-ethyl acetate-acetic acid 8:1:1 as the eluent.

Aufarbeitung

  1. extractionextracted into ethyl acetate
  2. customevaporated
  3. customThe product was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-93c972d9802948868638b6370fcf9ec8
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318785B2

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