Phosphorus trichloride → (3aS,6aS)-Ethyl 1-((6-(5-cyano-2-hydroxy-1H-indol-3-yl)pyridin-3-yl)methyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

HRID 1881339Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1881339
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([OH:12])=[C:6]2[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][N:20]2[CH2:24][CH2:23][C@H:22]3[CH2:25][N:26]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:27][C@@H:21]23)=[CH:15][N+:14]=1[O-])#[N:2].P(Cl)(Cl)Cl>>[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([OH:12])=[C:6]2[C:13]1[N:14]=[CH:15][C:16]([CH2:19][N:20]2[CH2:24][CH2:23][C@H:22]3[CH2:25][N:26]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:27][C@@H:21]23)=[CH:17][CH:18]=1)#[N:2]

Komponenten

3

Edukt 2

HCID 24387Phosphorus trichlorideHCID 178473354HCID 178473354, Verbindung

Produkt 1

HCID 136414313(3aS,6aS)-Ethyl 1-((6-(5-cyano-2-hydroxy-1H-indol-3-yl)pyridin-3-yl)methyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

Versuchsvorschrift

The titled compound was prepared in analogy to example 4.2 starting from 2-(5-cyano-2-hydroxy-1H-indol-3-yl)-5-(((3aS,6aS)-5-(ethoxy-carbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide (100 mg) and phosphorus trichloride (123 mg). The obtained crude product was used without further purification in the next reaction step.

Aufarbeitung

  1. customThe obtained crude product
  2. customwas used without further purification in the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-f836f0a2f3284415a2eeb6b9b08ed583
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318793B2

Notizen zur Reaktion

Wird geladen…