Methyl 4-benzyloxycarbonyl-2-fluorobenzoate → 1-Methyl 2-fluoro-1,4-benzenedicarboxylate
Reaktionsgleichung
C([O:8][C:9]([C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([F:21])[CH:12]=1)=[O:10])C1C=CC=CC=1>C(O)C.[C].[Pd]>[F:21][C:13]1[CH:12]=[C:11]([CH:20]=[CH:19][C:14]=1[C:15]([O:17][CH3:18])=[O:16])[C:9]([OH:10])=[O:8]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Catalytic amount of 10 wt % palladium carbon was added to a solution of methyl 4-benzyloxycarbonyl-2-fluorobenzoate (35.4 mg, 0.123 mmol) in ethanol (2 mL), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. After completion of the reaction, the mixture was filtered through celite and the filtrate was concentrated to obtain 26.0 mg of the desired product as a colorless solid (yield 100%).