Sodium Hydroxide → 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid

HRID 1881633Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1881633
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([CH3:14])[N:12]=[C:11]([C:15](=[N:17][NH:18][C:19]([C:21]3[S:25][C:24]([C:26]([O:28]C)=[O:27])=[CH:23][CH:22]=3)=[O:20])[CH3:16])[C:10]=2[OH:30])[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([CH3:14])[N:12]=[C:11]([C:15](=[N:17][NH:18][C:19]([C:21]3[S:25][C:24]([C:26]([OH:28])=[O:27])=[CH:23][CH:22]=3)=[O:20])[CH3:16])[C:10]=2[OH:30])[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 72359955methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate

Produkt 1

HCID 723599245-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acidAusbeute 78,6 %

Versuchsvorschrift

From methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (200 mg, 0.43 mmol) and 1 M sodium hydroxide aqueous solution (2.13 mL, 2.13 mmol), 153.3 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 84%).

Quellen und Nachweise

ORD-Eintrag
ord-687fa1c446b744789e6c80e63a621217
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318796B2

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