HCID 25234931, Verbindung → Apricitabine, (+)-

HRID 1881706Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1881706
C([O:9][CH2:10][C@@H:11]1[S:15][C@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH:21]C(=O)C3C=CC=CC=3)=[N:19][C:17]2=[O:18])[CH2:13][O:12]1)(=O)C1C=CC=CC=1>N>[OH:9][CH2:10][C@@H:11]1[S:15][C@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH2:21])=[N:19][C:17]2=[O:18])[CH2:13][O:12]1

Komponenten

3

Edukt 1

HCID 25234931HCID 25234931, Verbindung

Produkt 1

HCID 468214Apricitabine, (+)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 222AmmoniaLösungsmittel

Versuchsvorschrift

2-(S)-benzoyloxymethyl-4-(S)—(N-benzoylcytosin-1-yl)-1,3-oxathiolane (1.0 g, 0.0022 mol) was dissolved in a methanolic ammonia (approximately 2M) solution (20 mL). The initial slurry was stirred overnight. After overnight stirring, the resulting clear solution was evaporated to dryness and slurried in acetone (20 mL). This yielded off-white powdery solid which was filtered and washed with acetone (2×10 mL), and dried to yield the product. 0.47 g (88%).

Aufarbeitung

  1. stirringAfter overnight stirring
  2. customthe resulting clear solution was evaporated to dryness
  3. filtrationThis yielded off-white powdery solid which was filtered
  4. washwashed with acetone (2×10 mL)
  5. customdried
  6. customto yield the product

Quellen und Nachweise

ORD-Eintrag
ord-6b36288fdd60451b99de7292bb93f010
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08318934B2

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