1-Hydroxybenzotriazole → 2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(2R,3R,7R)-2,3-diphenyl-1,4-dioxaspiro[4.4]non-7-yl]-N-methoxy-N-methylpropaneamide

Reaktionsgleichung

Cl.[CH3:2][O:3][NH:4][CH3:5].[Cl:6][C:7]1[CH:8]=[C:9]([CH:17]([CH2:21][C@H:22]2[CH2:42][CH2:41][C:24]3([O:28][C@H:27]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[C@@H:26]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[O:25]3)[CH2:23]2)[C:18]([OH:20])=O)[CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14].Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1>C(#N)C.C(OCC)(=O)C.C(N(CC)CC)C>[Cl:6][C:7]1[CH:8]=[C:9]([CH:17]([CH2:21][C@H:22]2[CH2:42][CH2:41][C:24]3([O:28][C@H:27]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)[C@@H:26]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[O:25]3)[CH2:23]2)[C:18]([N:4]([O:3][CH3:2])[CH3:5])=[O:20])[CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14]