HCID 23508505, Verbindung → HCID 23508424, Verbindung

HRID 1883670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1883670
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24]CC3C=CC=CC=3)=[CH:20][CH:19]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[H][H]>[C].[Pd].O1CCOCC1>[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=[O:3])=[O:4]

Komponenten

5

Edukt 2

HCID 23508505HCID 23508505, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 23508424HCID 23508424, VerbindungAusbeute 92,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture composed of 350 mg of 4-[N-(4-benzyloxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate, 350 mg of 10% palladium-carbon, and 10 ml of dioxane was stirred for 2 days under an atmospheric pressure of hydrogen. The reaction mixture was filtered to remove any insoluble matter, and the solvent was distilled off from the filtrate. Thus, there was obtained 260 mg of 4-[N-(4-hydroxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customto remove any insoluble matter
  3. distillationthe solvent was distilled off from the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-e709158e422a405eaf229008c5119fb2
Quelldatensatz
uspto-grants-2004_07
Patentnummer
US06762205B1

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