Hydrochloric Acid → 3-(Pyridin-3-yl)-4-phenyl-1,2,5-thiadiazole-1,1-dioxide Hydrochloride

HRID 18838

Reaktionsgleichung

Reaktionsgleichung von HRID 18838
[ClH:1].[C:2]1([C:8](=O)[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=O)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:18]([NH2:22])([NH2:21])(=[O:20])=[O:19]>CO>[ClH:1].[N:13]1[CH:14]=[CH:15][CH:16]=[C:11]([C:9]2[C:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:22][S:18](=[O:20])(=[O:19])[N:21]=2)[CH:12]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 82267SulfamideHCID 109875561-Phenyl-2-(pyridin-3-yl)ethan-1,2-dione

Produkt 1

HCID 685697783-(Pyridin-3-yl)-4-phenyl-1,2,5-thiadiazole-1,1-dioxide Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Hydrogen chloride gas is bubbled into a solution of 1-phenyl-2-(pyridin-3-yl)ethan-1,2-dione (1.63 g, 7.7 mmol, J. Org. Chem., 1999, 64, 6102) and sulfamide (750 mg, 7.7 mmol) in methanol (10 mL) until the solution begins to reflux. The gas flow is turned off, and the solution stirred at 65° C. for 3 h then cooled to rt. The solid that formed is filtered and dried to give 2.06 g of the product 497. MS: m/z 272 (M++1).

Aufarbeitung

  1. temperatureto reflux
  2. temperaturethen cooled to rt
  3. customThe solid that formed
  4. filtrationis filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2436acb9f8224b238af4c95ea2451d0c
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741493B2

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