HCID 12150103, Verbindung → HCID 12150104, Verbindung

HRID 1884608Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1884608
C([O:5][C:6]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([NH:18][C:19]([NH:21][C:22]2[CH:27]=[C:26]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:25]=[C:24]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:23]=2[O:37][CH3:38])=[O:20])=[CH:10][CH:9]=1)=[O:7])(C)(C)C>[Au].C(O)(C(F)(F)F)=O>[C:28]([C:26]1[CH:25]=[C:24]([NH:32][S:33]([CH3:36])(=[O:35])=[O:34])[C:23]([O:37][CH3:38])=[C:22]([NH:21][C:19](=[O:20])[NH:18][C:11]2[C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]([C:6]([OH:7])=[O:5])=[CH:9][CH:10]=2)[CH:27]=1)([CH3:31])([CH3:29])[CH3:30]

Komponenten

4

Edukt 1

HCID 12150103HCID 12150103, Verbindung

Produkt 1

HCID 12150104HCID 12150104, VerbindungAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23985GoldKatalysatorHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

To a 0° C. solution of 10 mL of TFA was added 878 mg (1.9 mmol) of 4-[3-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalene-1-carboxylic acid tert-butyl ester. The clear, light gold reaction was allowed to warm to room temperature, and kept there for 1 h. After this time, the reaction was concentrated in vacuo, and then diluted with toluene. The toluene was then removed in vacuo and the pale white solid was triturated with ether to provide 682 mg (89%) of the title compound.

Aufarbeitung

  1. concentrationAfter this time, the reaction was concentrated in vacuo
  2. additiondiluted with toluene
  3. customThe toluene was then removed in vacuo
  4. customthe pale white solid was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-a74cbf86aec6495b880a69bcde8de4c6
Quelldatensatz
uspto-grants-2004_07
Patentnummer
US06765009B2

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