Hydrochloric Acid → HCID 19876799, Verbindung

HRID 1886040Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886040
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[NH:11][CH2:12][CH2:13][NH:14]C(=O)C.Cl>CO>[NH2:14][CH2:13][CH2:12][NH:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 19876826HCID 19876826, Verbindung

Produkt 1

HCID 19876799HCID 19876799, VerbindungAusbeute 77,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-[2-[(1-methyl-1H-benzimidazol-2-yl)amino]ethyl]acetamide (2.32 g, 9.98 mmol), 2N HCl (20 mL), and MeOH (20 mL) was heated under reflux for 20 hours. The mixture was concentrated, diluted with H2O, made basic (pH9) with 2.5N NaOH, and extracted with EtOAc. The combined extracts were dried and concentrated to give a brown oil. Purification by flash chromatography (eluent 10% MeOH/CH2Cl2) gave a yellow oil 1.47 g (77%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 20 hours
  3. concentrationThe mixture was concentrated
  4. additiondiluted with H2O
  5. extractionextracted with EtOAc
  6. customThe combined extracts were dried
  7. concentrationconcentrated
  8. customto give a brown oil
  9. customPurification by flash chromatography (eluent 10% MeOH/CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-7321103da4424e62b67272e0136ebb39
Quelldatensatz
uspto-grants-1992_09
Patentnummer
US05149700

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