2,6-Xylyl isothiocyanate → N-(2,6-Dimethylphenyl)-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarbothioamide

HRID 1886585Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886585
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH:7]1[CH2:10][NH:9][CH2:8]1.C(N1CC(OC2C=CC=C(C(F)(F)F)C=2)C1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:44][C:45]1[CH:50]=[CH:49][CH:48]=[C:47]([CH3:51])[C:46]=1[N:52]=[C:53]=[S:54]>C(Cl)Cl>[CH3:51][C:47]1[CH:48]=[CH:49][CH:50]=[C:45]([CH3:44])[C:46]=1[NH:52][C:53]([N:9]1[CH2:10][CH:7]([O:6][C:5]2[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:1])([F:14])[F:15])[CH:4]=2)[CH2:8]1)=[S:54]

Komponenten

5

Edukt 3

HCID 879762,6-Xylyl isothiocyanateHCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidineHCID 117286941-Benzhydryl-3-[3-(trifluoromethyl)phenoxy]azetidine

Produkt 1

HCID 15053383N-(2,6-Dimethylphenyl)-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarbothioamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Crude 3-[3-(trifluoromethyl)phenoxy]azetidine from catalytic debenzylation of 30.0 g (0.078 mole) of 1-benzhydryl-3-[3-(trifluoromethyl)phenoxy]azetidine was dissolved in 100 ml of methylene chloride and treated dropwise under a nitrogen atmosphere with a solution of 12.7 g (0.078 mole) of 2,6-dimethylphenylisothiocyanate in 25 ml of methylene chloride. The product began to precipitate during the addition and an additional 50 ml of methylene chloride was added to facilitate stirring. After stirring overnight at ambient temperature, the product was collected by filtration (13.5 g, m.p. 196°-199° C.). A 6.0 g sample was recrystallized from isopropanol to give 5.3 g of product, m.p. 197°-199° C.

Aufarbeitung

  1. customto precipitate during the addition
  2. additionan additional 50 ml of methylene chloride was added
  3. stirringAfter stirring overnight at ambient temperature
  4. filtrationthe product was collected by filtration (13.5 g, m.p. 196°-199° C.)
  5. customA 6.0 g sample was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-0f5c8f17eb164c4eb94013df634e2dd6
Quelldatensatz
uspto-grants-1992_09
Patentnummer
US05151418

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