HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Boron tribromide → 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Boron tribromide | HCID 25134 | — |
| Edukt | 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline | HCID 57647053 | — |
| Edukt | 6-Isoquinolinol, 7-bromo- | HCID 135854837 | — |
| Produkt | 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline | HCID 136092899 | 42,4% |
Reaktionsschritte
1.02 g of 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline (87) were treated with boron tribromide as described for the synthesis of compound 1 to give 410 mg of the desired product 88. LCMS Method # 1, retention time 1.04 min, detected mass 256.00 [M+H]+
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08501736B2 |
| Quelldatensatz | uspto-grants-2013_08 |
| ORD ID | ord-b3ee4ab09bab40819a0ef29c1f391716 |
| Quellennotiz | uspto-grants-2013_08 |