Azobisisobutyronitrile → 3-bromomethyl-7-chloro-1-phenyl-1H-quinolin-4-one

In a 50 mL round-bottomed flask, 7-chloro-3-methyl-1-phenyl-1H-quinolin-4-one (0.142 g, 0.526 mmol), NBS (103 mg, 0.579 mol) and AIBN (13.0 mg, 0.079 mmol) were combined with carbon tetrachloride (3.5 mL) to give a colorless solution. The reaction mixture was heated at 115° C. for 1 h. The reaction mixture was cooled to room temp and then cooled to 0° C. The mixture was filtered to remove succinimide and the filtrate was concentrated. The crude product was used in the next step without further purification.

1. customto give a colorless solution
2. temperatureThe reaction mixture was cooled to room temp
3. temperaturecooled to 0° C
4. filtrationThe mixture was filtered
5. customto remove succinimide
6. concentrationthe filtrate was concentrated
7. customThe crude product was used in the next step without further purification

ORD-Eintrag

ord-92c9e29e40264b41b7ed6f9bc1c9ee64

Quelldatensatz

uspto-grants-2013_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08501732B2