Methyl chloroglyoxylate → HCID 71208654, Verbindung

HRID 1887828Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1887828
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.Cl[C:20](=[O:25])[C:21]([O:23][CH3:24])=[O:22]>C1(C)C=CC=CC=1>[CH3:24][O:23][C:21](=[O:22])[C:20]([N:12]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[C:8](=[O:11])[CH2:9][CH3:10])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:25]

Komponenten

4

Edukt 2

HCID 79846Methyl chloroglyoxylateHCID 71208293HCID 71208293, Verbindung

Produkt 1

HCID 71208654HCID 71208654, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a solution of 1-(4-fluoro-2-phenylamino-phenyl)-propan-1-one (6.0 g, 24.7 mmol) in toluene (75 mL) was added methyl chlorooxoacetate (14.2 mL, 148 mmol) at room temperature under nitrogen. The reaction mixture was heated at reflux at 110° C. for 16 hr. The reaction mixture was concentrated under vacuum to afford N-(5-fluoro-2-propionyl-phenyl)-N-phenyl-oxalamic acid methyl ester. The crude product was used in the next step without further purification.

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. concentrationThe reaction mixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4d9663461e394b7b9525502a46cbb910
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501732B2

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