Trifluoroacetic acid → (3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acid

HRID 1888194Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1888194
C([O:5][C:6](=[O:16])[CH2:7][N:8]1[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[C:9]1=[O:15])(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH3:14][N:10]1[CH2:11][CH2:12][CH2:13][N:8]([CH2:7][C:6]([OH:16])=[O:5])[C:9]1=[O:15]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59011720Tert-butyl(3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate

Produkt 1

HCID 57907519(3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acidAusbeute 1.012,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 0.090 g (0.39 mmol) of tert-butyl(3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate from step B in 4 mL of anhydrous dichloromethane was added 1 mL of TFA. The resulting mixture was stirred at ambient temperature for 6 h then evaporated to dryness in vacuo to afford the title compound as an off-white gum (0.68 g, 99%), LC-MS: m/z (ES) 173 (MH)+.

Aufarbeitung

  1. customthen evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e21f4856512d47c4be1bd028289f1ba8
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501786B2

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