Potassium Hydroxide → HCID 178451813, Verbindung

HRID 1888208Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1888208
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O-:21])=[O:20])[CH2:15][CH2:14]1.[OH-:22].[K+]>CC(O)(C)C>[NH2:12][C:11]([C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]2[C:8]=1[NH:7][N:6]=[C:5]2[CH:13]1[CH2:14][CH2:15][N:16]([C:19]([O:21][C:4]([CH3:8])([CH3:5])[CH3:3])=[O:20])[CH2:17][CH2:18]1)=[O:22]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 178509435HCID 178509435, Verbindung

Produkt 1

HCID 178451813HCID 178451813, VerbindungAusbeute 191,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

To 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (0.30 g, 0.74 mmols) in 2-methyl-2-propanol (30 mL) was added KOH (0.45 g, 7.4 mmol). The reaction mixture was heated at reflux overnight. After cooling, the solvent was evaporated and the residue was redissovled in ethyl acetate (150 mL) and filtered through a pad of silica gel to give the title compound (300 mg) as a yellow solid (99%).

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux overnight
  3. temperatureAfter cooling
  4. customthe solvent was evaporated
  5. filtrationfiltered through a pad of silica gel

Quellen und Nachweise

ORD-Eintrag
ord-6f971cba14fc424a903f576721d2ba23
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501780B2

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