Trifluoroacetic acid → HCID 178509434, Verbindung

HRID 1888211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1888211
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178451811HCID 178451811, Verbindung2×

Produkt 1

HCID 178509434HCID 178509434, VerbindungAusbeute 147,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 1,1-dimethylethyl 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (Intermediate 3) (0.200 g, 0.493 mmols) and trifluoroacetic acid (0.25 mL) in dichloromethane (5 mL) was stirred at room temperature for 2 hrs. The solution was cooled and the solvent removed in vacuo to give the crude amine (222 mg) trifluoroacetate salt, which was used in the next step without further purification.

Aufarbeitung

  1. temperatureThe solution was cooled
  2. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fb808721c9014c93b9d0ec8234f112cf
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501780B2

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