(2-Bromo-1,3-thiazol-4-yl)methanol → 1-(2-Bromothiazol-4-ylmethyl)-piperidine
Reaktionsgleichung
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7]O)[N:6]=1.BrC1C=C(F)C(C[N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=C(F)C=1>>[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:6]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from (2-bromothiazol-4-yl)-methanol, following the procedure outlined above for 1-(4-bromo-2,6-difluoro-benzyl)-piperidine, to afford the title compound as a yellow oil. 1H NMR (CDCl3, 300 MHz): 7.09 (s, 1H), 3.61 (d, J=0.9 Hz, 2H), 3.19 (t, J=5.4 Hz, 1H), 2.45 (t, J=5.1 Hz, 4H), 1.69-1.62 (m, 4H), 1.48-1.41 (m, 2H). LCMS (Method B): RT=0.8 min, M+H+=261/263.
Quellen und Nachweise
- ORD-Eintrag
- ord-e00e427e75414230800b01e1ff4c63db
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08501765B2
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