4-t-Butylbenzenesulfonyl chloride → N-(2-benzoyl-4-chloro-3-methoxy-phenyl)-4-tert-butyl-benzenesulfonamide

HRID 18886Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 18886
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[C:6]([O:16][CH3:17])[C:5]([Cl:18])=[CH:4][CH:3]=1.[C:19]([C:23]1[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:24]=1)([CH3:22])([CH3:21])[CH3:20]>>[C:8]([C:7]1[C:6]([O:16][CH3:17])=[C:5]([Cl:18])[CH:4]=[CH:3][C:2]=1[NH:1][S:29]([C:26]1[CH:27]=[CH:28][C:23]([C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:24][CH:25]=1)(=[O:31])=[O:30])(=[O:9])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 21107378(6-Amino-3-chloro-2-methoxy-phenyl)-phenyl-methanone

Produkt 1

HCID 11385576N-(2-benzoyl-4-chloro-3-methoxy-phenyl)-4-tert-butyl-benzenesulfonamide

Versuchsvorschrift

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 131 mg of ((6-Amino-3-chloro-2-methoxy-phenyl)-phenyl-methanone and 116 mg of 4-tert-butyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.23 (s, 9H), 3.74 (s, 3H), 6.73 (d, 1H, J=2.8 Hz), 7.16 (dd, 1H, J=9.2 Hz, 3.2 Hz), 7.33 (d, 2H, J=8.4 Hz), 7.50 (d, 2H, J=6.0 Hz), 7.56 (d, 2H, J=8.8 Hz), 7.68 (d, 1H, J=9.2 Hz), 8.82 (d, 2H, J=6.4 Hz), 9.38 (s, 1H). MS: m/z 458.1 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-c1e02279109d4888b8af682b9f9e0983
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741519B2

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