Reaktionsgleichung
[CH2:1]([C:5]1=[CH:6][N:7]([C:18]([CH3:21])([CH3:20])[CH3:19])[S:8]/[C:9]/1=[N:10]\[C:11]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)=[O:12])[CH2:2][CH2:3][CH3:4].[CH2:22]([O:24][C:25](Cl)=[O:26])[CH3:23]>>[CH2:1]([C:5]1=[CH:6][N:7]([C:18]([CH3:20])([CH3:19])[CH3:21])[S:8]/[C:9]/1=[N:10]\[C:11]([CH:13]1[CH2:17][CH2:16][N:15]([C:25]([O:24][CH2:22][CH3:23])=[O:26])[CH2:14]1)=[O:12])[CH2:2][CH2:3][CH3:4]Komponenten
3
Versuchsvorschrift
The product from Example 104B and ethylchloroformate (Aldrich) were processed using the method described in Example 102 to afford the title compound. 1H NMR (DMSO-d6) δ ppm 0.91 (t, J=7.3 Hz, 3H), 1.18 (t, J=6.9 Hz, 3H), 1.24-1.37 (m, 3H), 1.51-1.64 (m, 3H), 1.58 (s, 9H), 2.05-2.14 (m, 2H), 2.61-2.66 (m, 2H), 3.21-3.28 (m, 1H), 3.49-3.64 (m, 2H), 4.02 (q, J=7.1 Hz, 2H), 8.57 (s, 1H). (ESI+) m/z 410 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-000b80d7113e4598b34f0296695eedea
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08501794B2
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