Ammonia → HCID 178441303, Verbindung

HRID 1888684

Reaktionsgleichung

Reaktionsgleichung von HRID 1888684
[C:1]([N:5]1[CH:9]=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[C:7](=[NH:14])[S:6]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([OH:28])(=O)[C:16]1([CH2:26][CH2:25][CH:21]([C:22](O)=[O:23])[C:18]1([CH3:20])[CH3:19])[CH3:17].[NH3:29]>CO>[CH2:10]([C:8]1=[CH:9][N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6]/[C:7]/1=[N:14]\[C:22]([C@H:21]1[CH2:25][CH2:26][C@@:16]([CH3:17])([C:15]([NH2:29])=[O:28])[C:18]1([CH3:20])[CH3:19])=[O:23])[CH2:11][CH2:12][CH3:13]

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 214911,2,2-Trimethyl-1,3-cyclopentanedicarboxylic acidHCID 668672282-tert-Butyl-4-butylisothiazol-5(2H)-imine

Produkt 1

HCID 178441303HCID 178441303, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The product from Example 92B and the (+) camphoric acid (Aldrich) were processed using the method described in Example 170 except that the methanol used to trap the intermediate was saturated with ammonia solution instead of methanol to afford the title compound. 1H NMR (DMSO-d6) δ 0.50 (s, 3H), 0.90 (t, J=7.2 Hz, 3H), 1.19 (s, 3H), 1.23-1.44 (m, 3H), 1.26 (s, 3H), 1.57 (s, 9H), 1.57-1.71 (m, 3H), 1.93-2.06 (m, 1H), 2.71-2.82 (m, 1H), 2.62-2.69 (m, 3H), 7.01 (s, 1H), 6.75 (s, 1H), 8.50 (s, 1H). MS (ESI+) m/z 394 (M+H)+. Anal. calcd. for C11H35N3O2S: C, 64.08; H, 8.96; N, 10.68. Found: C, 64.26; H, 9.10; N, 10.65.

Aufarbeitung

  1. customused to trap

Quellen und Nachweise

ORD-Eintrag
ord-a7405d8924b6428ca7d618916c83d8e4
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501794B2

Verknüpfte Notizen

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