N-Acetylsulfanilyl chloride → N-[4-(2-Benzoyl-4-chloro-phenylsulfamoyl)-phenyl]-acetamide

HRID 18888

Reaktionsgleichung

Reaktionsgleichung von HRID 18888
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[C:17]([NH:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1)(=[O:19])[CH3:18]>>[C:9]([C:3]1[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=1[NH:1][S:27]([C:24]1[CH:23]=[CH:22][C:21]([NH:20][C:17](=[O:19])[CH3:18])=[CH:26][CH:25]=1)(=[O:29])=[O:28])(=[O:10])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

3

Edukt 2

HCID 8481N-Acetylsulfanilyl chlorideHCID 128702-Amino-5-chlorobenzophenone

Produkt 1

HCID 3481101N-[4-(2-Benzoyl-4-chloro-phenylsulfamoyl)-phenyl]-acetamide

Versuchsvorschrift

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 115 mg of (2-amino-5-chloro-phenyl)-phenyl-methanone and 117 mg of 4-Acetylamino-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 2.16 (s, 3H), 7.26 (b, 1H), 7.33 (d, 1H, J=2.4 Hz), 7.39 (m, 6H), 7.46 (dd, 1H, J=8.4 Hz, 2.4 Hz), 7.55 (m, 3H), 7.71 (d, 1H, J=8.8 Hz), 9.74 (s, 1H). MS: m/z 429.0 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-b3da01bb68d94b3588fcb7911db29b30
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741519B2

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