Hydrazine → 4-Methyl-1,3-thiazole-2-carbohydrazide

HRID 1889049

Reaktionsgleichung

Reaktionsgleichung von HRID 1889049
[CH3:1][C:2]1[N:3]=[C:4]([C:7]([O:9]CC)=O)[S:5][CH:6]=1.[NH2:12][NH2:13]>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:7]([NH:12][NH2:13])=[O:9])[S:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 567306Ethyl 4-methyl-1,3-thiazole-2-carboxylate

Produkt 1

HCID 112289374-Methyl-1,3-thiazole-2-carbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of ethyl 4-methyl-1,3-thiazole-2-carboxylate (I120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg.

Aufarbeitung

  1. temperaturethe solution was heated
  2. temperatureto reflux for 18 hours
  3. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-98724bebacf9490c9529b3bed35afff4
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501946B2

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