N-(3-Chloropropyl)dibutylamine → (2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N-(3-Chloropropyl)dibutylamine	HCID 96084	—
Edukt	Aluminum(III) Chloride	HCID 6451240	—
Edukt	(2-Butyl-5-nitro-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone	HCID 11473234	—
Edukt	(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone	HCID 22595055	—
Produkt	(2-Butyl-5-nitrobenzofuran-3-yl)(4-(3-dibutylaminopropoxy)phenyl)methanone	HCID 10209258	—

Reaktionsschritte

Industrial application of this last reaction step involves difficulties, because 2-n-butyl-3-(4-methoxybenzoyl)-5-nitro-benzofuran (X) is mutagenic, and aluminum chloride is harmful for the health. The resulting 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitro-benzofuran (XI) on reaction with dibutylamino-propylchloride furnishes 2-n-butyl-3-[4-(3-dibutylamino-propoxy)benzoyl]-5-nitro-benzofuran (XII)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08501971B2
Quelldatensatz	uspto-grants-2013_08
ORD ID	ord-4c3e52102a724d67b7057133efeb9934
Quellennotiz	uspto-grants-2013_08