p-Toluenesulfonic acid → 2-(2-(Methylthio)pyrimidin-4-yl)acetonitrile

HRID 1889227Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1889227
C(OC(=O)[CH:7]([C:16]#[N:17])[C:8]1[CH:13]=[CH:12][N:11]=[C:10]([S:14][CH3:15])[N:9]=1)(C)(C)C.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:15][S:14][C:10]1[N:9]=[C:8]([CH2:7][C:16]#[N:17])[CH:13]=[CH:12][N:11]=1

Komponenten

4

Edukt 2

HCID 6101p-Toluenesulfonic acidHCID 51034226Cyano-(2-methylthio-pyrimidin-4-yl)-acetic acid tert-butyl ester

Produkt 1

HCID 671997982-(2-(Methylthio)pyrimidin-4-yl)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of Intermediate cyano-(2-methylthio-pyrimidin-4-yl)-acetic acid tert-butyl ester (5.3 g, 20 mmol) in anhydrous toluene (100 mL) was added p-toluenesulfonic acid (800 mg). The mixture was heated to reflux for 8 h, cooled to room temperature and extracted with ethyl acetate. The organic layer was washed with 1N aqueous sodium hydroxide solution and brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel chromatography (3:1 hexanes/ethyl acetate eluant) to afford the title compound: 1H NMR 400 MHz (CDCl3) δ 8.56 (d, 1H), 7.12 (d, 1H), 3.84 (s, 2H), 2.57 (s, 3H); MS m/z: 166.0 (M+1).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 8 h
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with 1N aqueous sodium hydroxide solution and brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe crude product was purified by silica gel chromatography (3:1 hexanes/ethyl acetate eluant)

Quellen und Nachweise

ORD-Eintrag
ord-e052bdb625004a189e549896536fde1f
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501758B2

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