5-Amino-2-methylpyridine → N(8)-(2-Methoxy-benzyl)-N(2)-(6-methyl-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

Beteiligte Stoffe

Reaktionsschritte

N(8)-(2-Methoxy-benzyl)-N(2)-(6-methyl-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine was prepared from 6-Methyl-pyridin-3-ylamine (83.90 mg, 0.7758 mmol) and (2-chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(2-methoxy-benzyl)-amine (200.00 mg, 0.69268 mmol) in a manner analogous to Example 2d. Product isolated as a red foam (23.23 mg, 9%). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.51 (s, 1H), 8.74 (s, 1H), 8.10 (d, J=8.8 Hz, 1H), 7.97 (d, J=6.7 Hz, 1H), 7.23 (m, 2H), 7.15 (d, J=8.8 Hz, 1H), 7.03 (d, J=8.8 Hz, 1H), 6.87 (t, J=15.1, 7.4 Hz, 1H), 6.75 (t, J=14.1, 7.1 Hz, 1H), 6.32-6.23 (m, 2H), 4.47 (d, J=5.9 Hz, 1H), 3.87 (s, 3H), 2.39 (s, 3H). MS=361. (MH)+.

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