4-Chloro-o-anisic acid → (+/-)-4-Fluoro-2-methoxy-N-(4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4a-diaza-benzocyclohepten-9-yl)-benzamide

HRID 1890243

Reaktionsgleichung

Reaktionsgleichung von HRID 1890243
[NH2:1][CH:2]1[C:8]2=[N:9][C:10]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[CH:11][C:12](=[O:13])[N:7]2[CH2:6][CH2:5][O:4][CH2:3]1.[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[C:23]([O:30][CH3:31])[CH:22]=1.ClC1C=CC(C(O)=O)=C(OC)C=1>>[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:1][CH:2]2[C:8]3=[N:9][C:10]([C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)=[CH:11][C:12](=[O:13])[N:7]3[CH2:6][CH2:5][O:4][CH2:3]2)=[O:26])=[C:23]([O:30][CH3:31])[CH:22]=1

Komponenten

4

Edukt 3

HCID 936824-Chloro-o-anisic acidHCID 27745454-Fluoro-2-methoxybenzoic acidHCID 66846193(+/-) 9-Amino-2-pyridin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

Produkt 1

HCID 44159612(+/-)-4-Fluoro-2-methoxy-N-(4-oxo-2-pyridin-4-yl-5,6,8,9-tetrahydro-4H-7-oxa-1,4a-diaza-benzocyclohepten-9-yl)-benzamide

Versuchsvorschrift

By analogy with the method described in example 1 (step 1.4), using (+/−) 9-amino-2-pyridin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one and 4-fluoro-2-methoxy benzoic acid in place of (+/−)-9-amino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one and 4-chloro-2-methoxy-benzoic acid, the compound, 0.068 g (71%), was obtained as a powder.

Aufarbeitung

  1. customthe compound, 0.068 g (71%), was obtained as a powder

Quellen und Nachweise

ORD-Eintrag
ord-7bd987bb57674e3292dae1f2be6e633d
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507470B2

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