Aluminium lithium hydride → 1-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

HRID 1890519

Reaktionsgleichung

Reaktionsgleichung von HRID 1890519
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10](=[O:12])[CH3:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[CH:10]([OH:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 584330461-(Thieno[3,2-c]pyridin-2-yl)ethanone

Produkt 1

HCID 673049441-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1-(thieno[3,2-c]pyridin-2-yl)ethanone (D′-3) (3.5 g, 1 mmol) in anhydrous THF (50 mL) was added LiAlH4 (1.13 g, 1.5 mmol) in portions at 0° C. The suspension was stirred under this temperature for 1 h. The reaction mixture was quenched with saturated aqueous NH4Cl solution and filtered. The filtrate was washed with brine, concentrated, and then used for the next step without any further purification.

Aufarbeitung

  1. customThe reaction mixture was quenched with saturated aqueous NH4Cl solution
  2. filtrationfiltered
  3. washThe filtrate was washed with brine
  4. concentrationconcentrated
  5. customused for the next step without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-596329c447e34f76b860f4f8ff482604
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507487B2

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