Pyrazolo[1,5-a]pyriMidine-5-carbonitrile → Pyrazolo[1,5-a]pyrimidine-5-methanamine

HRID 1890572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1890572
[N:1]1[N:5]2[CH:6]=[CH:7][C:8]([C:10]#[N:11])=[N:9][C:4]2=[CH:3][CH:2]=1>N.CO.[Ni]>[N:1]1[N:5]2[CH:6]=[CH:7][C:8]([CH2:10][NH2:11])=[N:9][C:4]2=[CH:3][CH:2]=1

Komponenten

5

Edukt 1

HCID 23156341Pyrazolo[1,5-a]pyriMidine-5-carbonitrile

Produkt 1

HCID 67305688Pyrazolo[1,5-a]pyrimidine-5-methanamineAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of pyrazolo[1,5-a]pyrimidine-5-carbonitrile (2-2) (620 mg, 4.31 mmol) in NH3 in MeOH (5 mL) was added Raney Ni (100 mg). The reaction mixture was stirred at room temperature for 3 h under H2. The mixture was filtered, and the filtrate was concentrated to afford the title compound (600 mg). MS (m/z): 149 (M+1)+.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-323202553a024c9aa4c31514ed975056
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507487B2

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