Ammonia → HCID 67313715, Verbindung

HRID 1890580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1890580
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]#[N:11])[N:7]=[CH:6][C:5]=12.N>CO.[Ni]>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][NH2:11])[N:7]=[CH:6][C:5]=12

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 67305172Imidazo[1,2-a]pyrazine-6-carbonitrile

Produkt 1

HCID 67313715HCID 67313715, VerbindungAusbeute 86,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of imidazo[1,2-a]pyrazine-6-carbonitrile (5-1) (180 mg, 1.25 mmol) in methanol (15 mL) were added Raney nickel (slurry in water, 150 mg) and 1 N ammonia. The reaction mixture was stirred under H2 (1 atm) for 2 h. The mixture was filtered, and the filtrate was concentrated to afford the title compound (160 mg). MS (m/z): 149.1 (M+H)+

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-eb3c409c5f6d4994bc9a39b5bf1f8f09
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507487B2

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